Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 509)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0450288	0.1073840	0.6792367
Weighted median	23	-0.0073227	0.0550103	0.8941027
Inverse variance weighted	23	0.0385226	0.0416985	0.3555721
Simple mode	23	-0.0180407	0.0922971	0.8468247
Weighted mode	23	-0.0024747	0.0639323	0.9694721

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	24.30300	21	0.2786100
Inverse variance weighted	25.12993	22	0.2909018

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0051309	0.0060699	0.4074692

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.000791	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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