Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 508)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0594463	0.0998194	0.5578479
Weighted median	23	0.0500167	0.0577989	0.3868429
Inverse variance weighted	23	0.0288991	0.0390154	0.4588697
Simple mode	23	0.1790243	0.1097346	0.1170335
Weighted mode	23	0.1480722	0.0952791	0.1344319

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	17.34591	21	0.6899363
Inverse variance weighted	18.27048	22	0.6898368

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0054253	0.0056423	0.3472213

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005703	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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