Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 507)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0576217	0.0998214	0.5699097
Weighted median	23	0.0230106	0.0550099	0.6757283
Inverse variance weighted	23	0.0416302	0.0390158	0.2859683
Simple mode	23	-0.0207300	0.0910442	0.8219890
Weighted mode	23	0.0077387	0.0611160	0.9003894

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	16.92549	21	0.7156128
Inverse variance weighted	16.95578	22	0.7657977

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.000982	0.0056424	0.8634964

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005483	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8