Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 506)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0001600	0.0998203	0.9987362
Weighted median	23	0.0250165	0.0547085	0.6474782
Inverse variance weighted	23	0.0395144	0.0390155	0.3111620
Simple mode	23	0.0187581	0.0929649	0.8419460
Weighted mode	23	0.0286847	0.0678955	0.6767724

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	14.14174	21	0.8634341
Inverse variance weighted	14.32820	22	0.8894225

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0024364	0.0056423	0.6702818

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0004653	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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