Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 505)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1656689	0.0998192	0.1118377
Weighted median	23	-0.0969066	0.0538744	0.0720583
Inverse variance weighted	23	-0.0674379	0.0390155	0.0839000
Simple mode	23	-0.1136394	0.0972825	0.2552547
Weighted mode	23	-0.1111747	0.0695054	0.1239708

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	13.36861	21	0.8951652
Inverse variance weighted	14.51167	22	0.8823294

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0060324	0.0056423	0.2971427

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005303	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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