Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 504)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0351871	0.0998198	0.7279721
Weighted median	23	0.0320220	0.0546935	0.5582244
Inverse variance weighted	23	0.0541700	0.0390156	0.1650097
Simple mode	23	0.0451359	0.0966632	0.6451339
Weighted mode	23	0.0178599	0.0665254	0.7908407

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	19.38381	21	0.5605340
Inverse variance weighted	19.42649	22	0.6188657

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0011657	0.0056423	0.8383062

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006471	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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