Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 503)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0227384	0.0998212	0.8220115
Weighted median	23	0.0118110	0.0559707	0.8328706
Inverse variance weighted	23	-0.0080735	0.0390157	0.8360650
Simple mode	23	-0.0079211	0.0881842	0.9292394
Weighted mode	23	-0.0004559	0.0596428	0.9939695

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	14.05932	21	0.8670378
Inverse variance weighted	14.17178	22	0.8952706

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0018922	0.0056424	0.74069

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0004307	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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