Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 502)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1026517	0.0998198	0.3154755
Weighted median	23	-0.0241745	0.0577854	0.6756916
Inverse variance weighted	23	-0.0467920	0.0390150	0.2303991
Simple mode	23	-0.0136894	0.0983544	0.8905709
Weighted mode	23	-0.0113383	0.0811575	0.8901626

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	19.95003	21	0.5244281
Inverse variance weighted	20.31966	22	0.5630519

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0034304	0.0056423	0.5497277

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006593	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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