Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 501)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0425078	0.0998194	0.6745520
Weighted median	23	-0.0285696	0.0564147	0.6125615
Inverse variance weighted	23	-0.0680930	0.0390155	0.0809360
Simple mode	23	-0.0415138	0.0973305	0.6738705
Weighted mode	23	-0.0617978	0.0693349	0.3824160

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	16.52058	21	0.7397261
Inverse variance weighted	17.96964	22	0.7077869

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.006792	0.0056423	0.2420731

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006368	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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