Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 500)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1058672	0.1285484	0.4194452
Weighted median	23	0.0830147	0.0625898	0.1847305
Inverse variance weighted	23	-0.0375668	0.0494769	0.4476856
Simple mode	23	0.0673543	0.1464909	0.6501819
Weighted mode	23	0.0951534	0.0828224	0.2629417

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	34.82827	21	0.0294846
Inverse variance weighted	35.38089	22	0.0353367

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0041944	0.0072663	0.5699151

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0011002	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8