Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 50)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1989924	0.0998198	0.0593553
Weighted median	23	0.0634750	0.0557148	0.2545839
Inverse variance weighted	23	0.0500120	0.0390154	0.1998946
Simple mode	23	0.0605337	0.0829849	0.4734193
Weighted mode	23	0.0746862	0.0654286	0.2659386

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	14.30077	21	0.8563364
Inverse variance weighted	16.92997	22	0.7672149

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0091489	0.0056423	0.1198335

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005628	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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