Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 5)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0859328	0.1141613	0.4599671
Weighted median	23	0.0970872	0.0604862	0.1084692
Inverse variance weighted	23	0.0402349	0.0437908	0.3582009
Simple mode	23	0.0689591	0.1187653	0.5673884
Weighted mode	23	0.1019700	0.0837542	0.2363160

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	27.46788	21	0.1558977
Inverse variance weighted	27.71526	22	0.1853107

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0028063	0.006453	0.6680813

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008721	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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