Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 499)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1717145	0.1089284	0.1298799
Weighted median	23	0.0648311	0.0600688	0.2804624
Inverse variance weighted	23	0.0621597	0.0427625	0.1460564
Simple mode	23	0.1015716	0.0948408	0.2957925
Weighted mode	23	0.0741805	0.0714990	0.3107707

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	25.00744	21	0.2468421
Inverse variance weighted	26.42921	22	0.2337109

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0067278	0.0061572	0.2869153

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008778	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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