Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 498)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1002391	0.1066093	0.3577813
Weighted median	23	-0.0041283	0.0586519	0.9438864
Inverse variance weighted	23	0.0128724	0.0414724	0.7562678
Simple mode	23	-0.0291003	0.0951082	0.7625035
Weighted mode	23	-0.0040501	0.0667037	0.9521323

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	23.95374	21	0.2953055
Inverse variance weighted	24.85792	22	0.3039176

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0053652	0.0060261	0.3833765

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007565	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8