Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 497)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0718791	0.1259255	0.5741888
Weighted median	23	0.0961200	0.0562102	0.0872644
Inverse variance weighted	23	0.0356783	0.0481992	0.4591620
Simple mode	23	0.0972030	0.0915646	0.2999424
Weighted mode	23	0.1007741	0.0567923	0.0898329

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	33.42095	21	0.0417529
Inverse variance weighted	33.57619	22	0.0542156

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0022231	0.0071179	0.7578753

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0010428	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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