Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 496)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0247424	0.0998210	0.8066444
Weighted median	23	0.0071809	0.0574683	0.9005597
Inverse variance weighted	23	-0.0164624	0.0390157	0.6730663
Simple mode	23	0.0545526	0.1011287	0.5950036
Weighted mode	23	0.0520304	0.0697659	0.4636916

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	16.68211	21	0.7301867
Inverse variance weighted	16.69023	22	0.7802184

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0005085	0.0056424	0.9290483

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005112	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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