Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 495)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0390330	0.1096261	0.7253508
Weighted median	23	-0.0739281	0.0552280	0.1807010
Inverse variance weighted	23	-0.0636626	0.0428832	0.1376608
Simple mode	23	-0.0331374	0.0935532	0.7265546
Weighted mode	23	-0.0613984	0.0674826	0.3727674

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	25.32873	21	0.2332074
Inverse variance weighted	26.57804	22	0.2276928

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0063065	0.0061966	0.3203835

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008861	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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