Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 494)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1498146	0.0998197	0.1482804
Weighted median	23	0.0268278	0.0566982	0.6360925
Inverse variance weighted	23	0.0184865	0.0390947	0.6363090
Simple mode	23	0.0280708	0.0902870	0.7587981
Weighted mode	23	0.0496400	0.0707791	0.4904451

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	18.73419	21	0.6021871
Inverse variance weighted	22.08956	22	0.4545541

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0103354	0.0056423	0.0812094

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006762	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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