Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 493)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0917235	0.0998204	0.3685898
Weighted median	23	-0.0127668	0.0545898	0.8150867
Inverse variance weighted	23	-0.0006127	0.0390157	0.9874708
Simple mode	23	-0.0681334	0.0913573	0.4636888
Weighted mode	23	0.0056911	0.0641703	0.9301328

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	16.43529	21	0.7447168
Inverse variance weighted	17.44525	22	0.7383260

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0056704	0.0056423	0.3263523

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005287	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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