Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 492)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0306675	0.1057789	0.7747199
Weighted median	23	0.0374154	0.0538508	0.4871823
Inverse variance weighted	23	-0.0112115	0.0405714	0.7822864
Simple mode	23	0.0021243	0.0936281	0.9821035
Weighted mode	23	0.0428656	0.0622734	0.4984301

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	23.58191	21	0.3137537
Inverse variance weighted	23.78967	22	0.3583506

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0025718	0.0059791	0.6714845

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007234	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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