Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 491)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0427658	0.1324647	0.7500037
Weighted median	23	0.0355844	0.0542159	0.5116015
Inverse variance weighted	23	0.0321592	0.0505936	0.5250125
Simple mode	23	0.0636678	0.0904068	0.4886740
Weighted mode	23	0.0411325	0.0588328	0.4917891

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	36.98132	21	0.0169174
Inverse variance weighted	36.99464	22	0.0236879

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0006513	0.0074875	0.9315025

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0011415	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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