Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 490)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0579008	0.1193252	0.6325329
Weighted median	23	-0.0510087	0.0587558	0.3853133
Inverse variance weighted	23	-0.0039310	0.0458278	0.9316434
Simple mode	23	0.0863673	0.0993026	0.3938336
Weighted mode	23	-0.0139421	0.0700379	0.8440399

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	30.00840	21	0.0918194
Inverse variance weighted	30.35343	22	0.1101242

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0033143	0.0067448	0.628254

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009201	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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