Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 49)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0261486	0.0998204	0.7959077
Weighted median	23	0.0146864	0.0550621	0.7896810
Inverse variance weighted	23	0.0063517	0.0390155	0.8706769
Simple mode	23	-0.0091150	0.0949717	0.9244083
Weighted mode	23	0.0441054	0.0807867	0.5905946

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	13.73567	21	0.8806831
Inverse variance weighted	13.86079	22	0.9063461

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0019958	0.0056423	0.7270712

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0004208	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8