Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 489)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0955898	0.1177087	0.4258516
Weighted median	23	-0.0534037	0.0597639	0.3715476
Inverse variance weighted	23	0.0035676	0.0457153	0.9377959
Simple mode	23	-0.0908278	0.1107462	0.4209320
Weighted mode	23	-0.0627499	0.0785369	0.4328406

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	29.20164	21	0.1092440
Inverse variance weighted	30.20477	22	0.1135718

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0056511	0.0066535	0.4052691

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009155	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8