Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 488)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.2273629	0.0998180	0.0333146
Weighted median	23	0.1270495	0.0592987	0.0321504
Inverse variance weighted	23	0.0832836	0.0390152	0.0327899
Simple mode	23	0.0229438	0.1040680	0.8275391
Weighted mode	23	0.1578583	0.0738335	0.0438728

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	19.26520	21	0.5681320
Inverse variance weighted	21.72436	22	0.4764406

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.008848	0.0056422	0.1317875

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007964	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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