Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 487)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1277317	0.1168015	0.2865255
Weighted median	23	-0.0484192	0.0585642	0.4083665
Inverse variance weighted	23	-0.0028150	0.0460146	0.9512185
Simple mode	23	-0.1631764	0.1082034	0.1457684
Weighted mode	23	-0.1219564	0.0634186	0.0675146

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	28.75326	21	0.1200524
Inverse variance weighted	30.60173	22	0.1045577

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0076712	0.0066022	0.2583089

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009275	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8