Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 486)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0265829	0.0998207	0.7926005
Weighted median	23	0.0801973	0.0555082	0.1485183
Inverse variance weighted	23	0.0563724	0.0390157	0.1484959
Simple mode	23	0.1036436	0.0917013	0.2705513
Weighted mode	23	0.0756927	0.0605175	0.2241627

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	15.75958	21	0.7830034
Inverse variance weighted	15.86470	22	0.8225434

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0018294	0.0056423	0.7489772

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.000544	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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