Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 485)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0404626	0.0998205	0.6893174
Weighted median	23	0.0213739	0.0567643	0.7065169
Inverse variance weighted	23	0.0294344	0.0390156	0.4505921
Simple mode	23	0.0707675	0.0935613	0.4574478
Weighted mode	23	0.0258692	0.0688773	0.7108231

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	19.85384	21	0.5305352
Inverse variance weighted	19.86825	22	0.5912808

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0006772	0.0056423	0.9056016

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006193	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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