Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 483)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0246052	0.1137607	0.8308496
Weighted median	23	0.0063355	0.0539876	0.9065818
Inverse variance weighted	23	-0.0126294	0.0434554	0.7713349
Simple mode	23	-0.0499502	0.0916189	0.5911042
Weighted mode	23	-0.0105773	0.0609788	0.8638770

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	27.27492	21	0.1619377
Inverse variance weighted	27.29190	22	0.2003488

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0007354	0.0064303	0.9100312

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008301	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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