Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 482)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1797627	0.0998200	0.0861036
Weighted median	23	0.0033544	0.0563846	0.9525609
Inverse variance weighted	23	0.0421085	0.0390154	0.2804625
Simple mode	23	-0.0263916	0.1015816	0.7974287
Weighted mode	23	0.0019158	0.0747729	0.9797904

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	11.71966	21	0.9468786
Inverse variance weighted	13.96427	22	0.9027424

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0084534	0.0056423	0.1489624

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0004585	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8