Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 481)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1499593	0.1571445	0.3508004
Weighted median	23	0.0334707	0.0654078	0.6088445
Inverse variance weighted	23	-0.0326540	0.0622447	0.5998558
Simple mode	23	0.0660092	0.1127663	0.5642604
Weighted mode	23	0.0867936	0.0886456	0.3381716

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	52.04831	21	1.88e-04
Inverse variance weighted	55.99881	22	8.55e-05

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0112142	0.0088825	0.2206083

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0017179	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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