Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 480)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1053784	0.0998207	0.3031103
Weighted median	23	0.0052732	0.0559959	0.9249736
Inverse variance weighted	23	0.0368174	0.0390156	0.3453443
Simple mode	23	-0.0697099	0.0896614	0.4451565
Weighted mode	23	-0.0092437	0.0663637	0.8904889

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	17.56174	21	0.6765446
Inverse variance weighted	18.11855	22	0.6989367

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0042103	0.0056424	0.4638184

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.000576	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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