Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 48)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0176721	0.0998206	0.8611748
Weighted median	23	0.0082465	0.0571351	0.8852371
Inverse variance weighted	23	0.0313364	0.0390156	0.4218730
Simple mode	23	0.0166279	0.0974722	0.8661042
Weighted mode	23	0.0006610	0.0651808	0.9920002

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	15.32491	21	0.8063027
Inverse variance weighted	15.60942	22	0.8347861

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0030096	0.0056423	0.5993603

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0004926	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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