Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 479)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1204533	0.1177871	0.3181172
Weighted median	23	0.0769270	0.0559685	0.1692962
Inverse variance weighted	23	-0.0215413	0.0467806	0.6451749
Simple mode	23	0.0708079	0.0951759	0.4647675
Weighted mode	23	0.0838571	0.0643164	0.2057734

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	29.24080	21	0.1083393
Inverse variance weighted	31.62926	22	0.0839401

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0087198	0.0066579	0.2044435

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009676	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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