Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 478)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1751070	0.0998194	0.0939727
Weighted median	23	0.0425433	0.0580856	0.4639101
Inverse variance weighted	23	0.0295142	0.0390152	0.4493617
Simple mode	23	-0.0420341	0.0939478	0.6589463
Weighted mode	23	0.0547325	0.0672425	0.4243928

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	19.02988	21	0.5832235
Inverse variance weighted	21.54088	22	0.4875604

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0089409	0.0056423	0.127998

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006701	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8