Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 477)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0081757	0.1020391	0.9368983
Weighted median	23	-0.1102995	0.0554899	0.0468404
Inverse variance weighted	23	-0.1018880	0.0398787	0.0106205
Simple mode	23	-0.2547793	0.0951012	0.0137078
Weighted mode	23	-0.1211562	0.0657538	0.0789099

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	21.94427	21	0.4027273
Inverse variance weighted	22.98458	22	0.4026008

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0057549	0.0057677	0.329751

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009032	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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