Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 476)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0144472	0.0998203	0.8863021
Weighted median	23	0.0026369	0.0603150	0.9651280
Inverse variance weighted	23	0.0400418	0.0390155	0.3047467
Simple mode	23	-0.0112909	0.0976481	0.9089961
Weighted mode	23	-0.0139441	0.0773457	0.8585810

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	18.33118	21	0.6279607
Inverse variance weighted	18.40878	22	0.6814955

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0015718	0.0056423	0.7833022

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005897	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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