Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 474)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0461176	0.0998210	0.6488298
Weighted median	23	-0.0093429	0.0567250	0.8691763
Inverse variance weighted	23	-0.0118770	0.0390160	0.7608131
Simple mode	23	0.0019691	0.0868221	0.9821099
Weighted mode	23	-0.0001732	0.0623567	0.9978086

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	11.66121	21	0.9483158
Inverse variance weighted	11.80009	22	0.9613712

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0021027	0.0056424	0.7131322

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0003604	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8