Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 473)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.2044116	0.1025548	0.0593930
Weighted median	23	0.0352671	0.0585431	0.5469000
Inverse variance weighted	23	-0.0010036	0.0433542	0.9815318
Simple mode	23	-0.1119083	0.1068894	0.3064877
Weighted mode	23	0.0448982	0.0669449	0.5094083

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	22.16693	21	0.3899457
Inverse variance weighted	27.16543	22	0.2050107

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0126146	0.0057969	0.0411094

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008232	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8