Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 472)

Date: 22 April, 2022

Results from two sample MR:

method nsnp b se pval
MR Egger 23 0.0536434 0.1053189 0.6158226
Weighted median 23 -0.0443539 0.0603777 0.4625794
Inverse variance weighted 23 -0.0124579 0.0406612 0.7593134
Simple mode 23 -0.0566644 0.1037457 0.5904349
Weighted mode 23 -0.0631513 0.0769933 0.4208906

Heterogeneity tests

method Q Q_df Q_pval
MR Egger 23.37771 21 0.3241749
Inverse variance weighted 23.89531 22 0.3527411

Test for directional horizontal pleiotropy

egger_intercept se pval
-0.0040593 0.0059532 0.5027713

Test that the exposure is upstream of the outcome

snp_r2.exposure snp_r2.outcome correct_causal_direction steiger_pval
0.0357937 0.0007272 TRUE 0

Note - R2 values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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