Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 471)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0720938	0.0998212	0.4781198
Weighted median	23	-0.0142743	0.0537063	0.7904054
Inverse variance weighted	23	-0.0028924	0.0390159	0.9409032
Simple mode	23	-0.0166641	0.0878985	0.8513737
Weighted mode	23	-0.0100025	0.0604120	0.8700067

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	14.89749	21	0.8280600
Inverse variance weighted	15.56356	22	0.8369404

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0046049	0.0056424	0.4235886

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0004718	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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