Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 470)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1990117	0.0998200	0.0593331
Weighted median	23	-0.0007132	0.0549230	0.9896396
Inverse variance weighted	23	0.0255918	0.0417736	0.5401214
Simple mode	23	0.0208073	0.0958942	0.8302218
Weighted mode	23	-0.0143473	0.0637275	0.8239519

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	19.24453	21	0.5694571
Inverse variance weighted	25.22035	22	0.2866539

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0137928	0.0056423	0.0234115

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007773	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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