Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 47)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1723006	0.0998198	0.0990114
Weighted median	23	0.0967267	0.0572051	0.0908605
Inverse variance weighted	23	0.0837548	0.0390155	0.0318165
Simple mode	23	0.0494222	0.0937076	0.6031883
Weighted mode	23	0.0876568	0.0663733	0.2001877

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	11.67032	21	0.9480934
Inverse variance weighted	12.59908	22	0.9437435

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0054376	0.0056423	0.3461537

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005214	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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