Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 469)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0468186	0.1005262	0.6461992
Weighted median	23	0.0015229	0.0588061	0.9793389
Inverse variance weighted	23	0.0254229	0.0390154	0.5146508
Simple mode	23	-0.0222964	0.1122473	0.8443712
Weighted mode	23	-0.0301639	0.0890809	0.7381123

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	21.29845	21	0.4408521
Inverse variance weighted	21.91667	22	0.4648720

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0044364	0.0056822	0.4436671

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.000677	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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