Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 468)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0996473	0.1239710	0.4305204
Weighted median	23	0.0218948	0.0561490	0.6965806
Inverse variance weighted	23	0.0412684	0.0476351	0.3863007
Simple mode	23	0.0148315	0.1065722	0.8905829
Weighted mode	23	0.0485072	0.0638510	0.4555014

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	32.39123	21	0.0534186
Inverse variance weighted	32.79495	22	0.0648170

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0035851	0.0070075	0.6142651

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0010276	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8