Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 466)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.2072639	0.1059725	0.0639199
Weighted median	23	-0.0618079	0.0550736	0.2617445
Inverse variance weighted	23	-0.0373663	0.0432925	0.3880750
Simple mode	23	-0.0495716	0.0978338	0.6174120
Weighted mode	23	-0.0681714	0.0703330	0.3429490

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	23.66877	21	0.3093829
Inverse variance weighted	27.08812	22	0.2078988

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0104335	0.0059901	0.0961768

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008486	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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