Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 465)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1770513	0.0998198	0.0906145
Weighted median	23	-0.0120214	0.0609308	0.8435962
Inverse variance weighted	23	0.0279100	0.0390153	0.4743864
Simple mode	23	0.0266532	0.1001060	0.7925262
Weighted mode	23	0.0045762	0.0699485	0.9484281

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	19.03347	21	0.5829927
Inverse variance weighted	21.66836	22	0.4798266

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0091588	0.0056423	0.119457

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006721	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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