Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 464)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0714664	0.0998204	0.4819084
Weighted median	23	0.0663385	0.0565262	0.2405602
Inverse variance weighted	23	0.0165092	0.0390154	0.6721888
Simple mode	23	-0.0314059	0.0975416	0.7505114
Weighted mode	23	0.0546407	0.0682379	0.4318463

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	20.41641	21	0.4950395
Inverse variance weighted	20.77419	22	0.5347288

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0033749	0.0056423	0.5561421

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006349	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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