Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 463)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0594966	0.1318688	0.6564843
Weighted median	23	-0.0104531	0.0586165	0.8584635
Inverse variance weighted	23	0.0207307	0.0508775	0.6836680
Simple mode	23	-0.0059687	0.0943726	0.9501420
Weighted mode	23	-0.0183930	0.0610479	0.7660238

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	36.64887	21	0.0184649
Inverse variance weighted	37.41130	22	0.0213106

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0049267	0.0074538	0.5158211

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0011422	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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