Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 462)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0193351	0.1105410	0.8628232
Weighted median	23	0.0101376	0.0542484	0.8517592
Inverse variance weighted	23	0.0189242	0.0422127	0.6539332
Simple mode	23	0.0628280	0.0912472	0.4983054
Weighted mode	23	0.0229241	0.0694257	0.7443757

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	25.75342	21	0.2160077
Inverse variance weighted	25.75344	22	0.2624186

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-2.52e-05	0.0062483	0.9968157

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007875	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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